HIV strains in India resist some top broadly neutralising antibodies
Researchers have found that Indian strains of HIV were most effectively neutralised by bNAbs targeting the virus’s V3 glycan while antibodies aimed at the V1/V2 apex of the viral spike protein were fa
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In 1994, a landmark paper in Science reported the isolation of an antibody called b12from an HIV-infected individual. The study showed that while pooled plasma containing billions of antibodies from HIV patients could neutralise viruses isolated from only 3 of 12 patients, b12 alone achieved similar neutralisation in 8 of the 12, and that, with one-fifth the amount of antibody present in the pooled plasma.
Soon, other antibodies with similar properties were identified that were capable of neutralising a wide range of HIV variants at remarkably low concentrations. This was an exciting development, as researchers were beginning to realise that conventional antibodies, which are normally among the immune system’s most powerful defences, are largely ineffective against HIV. These new antibodies, called broadly neutralising antibodies (bNAbs), raised hopes that they might one day help bring an end to the pandemic.
2025-09-15
By
Anushka Tripathi
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